Changes in 5-HT7 serotonin receptor mRNA expression with aging in rat brain

被引：14

作者：

Kohen, R

Heidmann, DEA

Anthony, J

White, SS

Hamblin, MW

Szot, P

机构：

[1] Ctr Geriatr Res Educ & Clin, VA Puget Sound Hlth Care Syst, Seattle, WA 98108 USA

[2] VA Puget Sound Hlth Care Syst, Mental Illness Res Educ & Clin Ctr, Seattle, WA 98108 USA

[3] Univ Washington, Dept Psychiat & Behav Sci, Seattle, WA 98195 USA

来源：

MOLECULAR BRAIN RESEARCH | 2000年 / 79卷 / 1-2期

关键词：

in situ hybridization histochemistry; aging; circadian rhythm; hippocampus; spatial learning; psychiatric disorders;

D O I：

10.1016/S0169-328X(00)00103-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined 5-HT7 receptor mRNA expression with in situ hybridization histochemistry in the brains of young (3 months), middle-aged (12 months) and old rats (24 months). In the ventral CA3 area of the hippocampus 5-HT7 mRNA expression is reduced by approximately 30% between young and middle age without further decline between middle and old age. In other brain areas 5-HT7 mRNA expression is unaffected by age. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：163 / 168

页数：6

共 31 条

[1] 123I-5-I-R91150, a new single-photon emission tomography ligand for 5-HT2A receptors:: influence of age and gender in healthy subjects [J].