Progressive multifocal leukoencephalopathy in a haploidentical stem cell transplant recipient: A clinical, neuroradiological and virological response after treatment with risperidone

被引：29

作者：

Focosi, Daniele

Fazzi, Rita

Montanaro, Domenico

Emdin, Michele

Petrini, Mario

机构：

[1] Azienda Osped Univ Santa Chiara, Div Hematol, I-56100 Pisa, Italy

[2] CNR, Dept Neuroradiol, Pisa, Italy

[3] CNR, Dept Cardiovasc Med, Pisa, Italy

来源：

ANTIVIRAL RESEARCH | 2007年 / 74卷 / 02期

关键词：

immunosuppression; leukemia; progressive multifocal leukoencephalopathy; risperidone; ziprasidone;

D O I：

10.1016/j.antiviral.2006.10.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

JC virus (JCV) is a double-stranded DNA virus belonging to family Polyomaviridae. It causes progressive multifocal leukoencephalopathy (PML), mainly in immunosuppressed people. JCV had been shown to require the serotonin 2A receptor for host cell entry. We report a case of clinical, neuroradiological and virological response of biopsy-proven PML in a 33-year-old comatose woman after treatment with the anti-psychotic drug risperidone. Since risperidone is the tightest binding of current drugs to this receptor we think this may have blocked JCV entry in our patient, allowing her immune recovery and viral clearance. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：156 / 158

页数：3

共 9 条

[1] The atypical antipsychotic agents zisprasidone, risperdone and olanzapine as treatment for and prophylaxis against progressive multifocal leukoencephatopathy [J].