Sugar sensing based on induced pH changes

被引:30
作者
Kim, Youngmi [1 ]
Hilderbrand, Scott A. [1 ]
Weissleder, Ralph [1 ]
Tung, Ching-Hsuan [1 ]
机构
[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA 02129 USA
关键词
D O I
10.1039/b700741h
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A sensory assembly consisting of a pH sensitive NIR dye and an arylboronic acid shows ratiometric absorption changes with increased fluorescence intensity upon addition of sugar in aqueous media; this demonstrates a new signal transduction mechanism for the detection of sugar based on pH changes induced in the microenvironment of the sensory assembly.
引用
收藏
页码:2299 / 2301
页数:3
相关论文
共 23 条
[11]   Recognition of sugars and related compounds by ''reading-out''-type interfaces [J].
James, TD ;
Sandanayake, KRAS ;
Shinkai, S .
SUPRAMOLECULAR CHEMISTRY, 1995, 6 (1-2) :141-&
[12]   Saccharide sensing with molecular receptors based on boronic acid [J].
James, TD ;
Sandanayake, KRAS ;
Shinkai, S .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 1996, 35 (17) :1910-1922
[13]   Red to near IR fluorescent signalling of carbohydrates [J].
Kukrer, B ;
Akkaya, EU .
TETRAHEDRON LETTERS, 1999, 40 (51) :9125-9128
[14]   Colorimetric identification of carbohydrates by a pH Indicator/pH change inducer ensemble [J].
Lee, Jae Wook ;
Lee, Jun-Seok ;
Chang, Young-Tae .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (39) :6485-6487
[15]   POLYOL COMPLEXES AND STRUCTURE OF THE BENZENEBORONATE ION [J].
LORAND, JP ;
EDWARDS, JO .
JOURNAL OF ORGANIC CHEMISTRY, 1959, 24 (06) :769-774
[16]   Using indicator-displacement assays in test strips and to follow reaction kinetics [J].
Nguyen, BT ;
Wiskur, SL ;
Anslyn, EV .
ORGANIC LETTERS, 2004, 6 (15) :2499-2501
[17]   Non-invasive glucose sensors and improved informatics - the future of diabetes management [J].
Rohrscheib, M ;
Robinson, R ;
Eaton, RP .
DIABETES OBESITY & METABOLISM, 2003, 5 (05) :280-284
[18]   Chiral sugar recognition by a diboronic-acid-appended binaphthyl derivative through rigidification effect [J].
Takeuchi, M ;
Yoda, S ;
Imada, T ;
Shinkai, S .
TETRAHEDRON, 1997, 53 (25) :8335-8348
[19]   Fluorescence and CD spectroscopic sugar sensing by a cyanine-appended diboronic acid probe [J].
Takeuchi, M ;
Mizuno, T ;
Shinmori, H ;
Nakashima, M ;
Shinkai, S .
TETRAHEDRON, 1996, 52 (04) :1195-1204
[20]  
WULFF G, 1982, PURE APPL CHEM, V54, P2094