Viruses and Toll-like receptors

被引:46
作者
Finberg, RW [1 ]
Kurt-Jones, EA [1 ]
机构
[1] Univ Massachusetts, Sch Med, Dept Med, Worcester, MA 01605 USA
关键词
Toll-like receptors; viruses; interferons; cytokines;
D O I
10.1016/j.micinf.2004.08.013
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Production of inflammatory cytokines and type I interferons by mammalian cells is mediated through virus-specific activation of Toll-like receptors (TLRs). Known roles for different TLRs and speculation as to their roles in viral pathogenesis and immunity are discussed in this review. (C) 2004 Elsevier SAS. All rights reserved.
引用
收藏
页码:1356 / 1360
页数:5
相关论文
共 31 条
[1]   Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3 [J].
Alexopoulou, L ;
Holt, AC ;
Medzhitov, R ;
Flavell, RA .
NATURE, 2001, 413 (6857) :732-738
[2]   Hemagglutinin protein of wild-type measles virus activates Toll-like receptor 2 signaling [J].
Bieback, K ;
Lien, E ;
Klagge, IM ;
Avota, E ;
Schneider-Schaulies, J ;
Duprex, WP ;
Wagner, H ;
Kirschning, CJ ;
ter Meulen, V ;
Schneider-Schaulies, S .
JOURNAL OF VIROLOGY, 2002, 76 (17) :8729-8736
[3]   Toll-like receptor 4-dependent activation of dendritic cells by a retrovirus [J].
Burzyn, D ;
Rassa, JC ;
Kim, D ;
Nepomnaschy, I ;
Ross, SR ;
Piazzon, I .
JOURNAL OF VIROLOGY, 2004, 78 (02) :576-584
[4]   Human cytomegalovirus activates inflammatory cytokine responses via CD14 and toll-like receptor 2 [J].
Compton, T ;
Kurt-Jones, EA ;
Boehme, KW ;
Belko, J ;
Latz, E ;
Golenbock, DT ;
Finberg, RW .
JOURNAL OF VIROLOGY, 2003, 77 (08) :4588-4596
[5]   Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA [J].
Diebold, SS ;
Kaisho, T ;
Hemmi, H ;
Akira, S ;
Sousa, CRE .
SCIENCE, 2004, 303 (5663) :1529-1531
[6]   Does Toll-like receptor 3 play a biological role in virus infections? [J].
Edelmann, KH ;
Richardson-Burns, S ;
Alexopoulou, L ;
Tyler, KL ;
Flavell, RA ;
Oldstone, MBA .
VIROLOGY, 2004, 322 (02) :231-238
[7]   IL-12 receptor β1 and Toll-like receptor 4 increase IL-1β- and IL-18-associated myocarditis and Coxsackievirus replication [J].
Fairweather, D ;
Yusung, S ;
Frisancho, S ;
Barrett, M ;
Gatewood, S ;
Steele, R ;
Rose, NR .
JOURNAL OF IMMUNOLOGY, 2003, 170 (09) :4731-4737
[8]   The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling [J].
Funami, K ;
Matsumoto, M ;
Oshiumi, H ;
Akazawa, T ;
Yamamoto, A ;
Seya, T .
INTERNATIONAL IMMUNOLOGY, 2004, 16 (08) :1143-1154
[9]   Involvement of toll-like receptor 4 in innate immunity to respiratory syncytial virus [J].
Haynes, LM ;
Moore, DD ;
Kurt-Jones, EA ;
Finberg, RW ;
Anderson, LJ ;
Tripp, RA .
JOURNAL OF VIROLOGY, 2001, 75 (22) :10730-10737
[10]   Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8 [J].
Heil, F ;
Hemmi, H ;
Hochrein, H ;
Ampenberger, F ;
Kirschning, C ;
Akira, S ;
Lipford, G ;
Wagner, H ;
Bauer, S .
SCIENCE, 2004, 303 (5663) :1526-1529