Neuropathology of preclinical and clinical late-onset Alzheimer's disease

被引：74

作者：

Troncoso, JC

Cataldo, AM

Nixon, RA

Barnett, JL

Lee, MK

Checler, F

Fowler, DR

Smialek, JE

Crain, B

Martin, LJ

Kawas, CH

机构：

[1] Johns Hopkins Univ, Sch Med, Neuropathol Lab, Baltimore, MD 21205 USA

[2] Johns Hopkins Univ, Sch Med, Alzheimers Dis Res Ctr, Baltimore, MD 21205 USA

[3] Johns Hopkins Univ, Sch Med, Dept Pathol, Baltimore, MD 21205 USA

[4] Johns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA

[5] Johns Hopkins Univ, Sch Med, Dept Neurosci, Baltimore, MD 21205 USA

[6] McLean Hosp, Lab Mol Neurosci, Belmont, MA 02178 USA

[7] Harvard Univ, Sch Med, Dept Psychiat, Belmont, MA 02178 USA

[8] Harvard Univ, Sch Med, Dept Neuropathol, Belmont, MA 02178 USA

[9] Off Chief Med Examiner State Maryland, Baltimore, MD USA

[10] CNRS, Inst Pharmacol Mol & Cellulaire, F-06560 Valbonne, France

来源：

ANNALS OF NEUROLOGY | 1998年 / 43卷 / 05期

关键词：

D O I：

10.1002/ana.410430519

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report on the neuropathological examinations of a 74-year-old woman with Alzheimer's disease (AD) and of her 47-year-old nondemented daughter. The brain of the mother showed fully developed pathological changes of AD. By contrast, the brain of the daughter revealed only perineuronal deposition of diffuse amyloid in cerebral cortex and striking abnormalities of the endosomal-lysosomal system, without neurofibrillary, glial, or microglial changes. These observations suggest that amyloid deposition and endosomal-lysosomal changes are early events in late-onset AD and that they may precede the onset of dementia by several decades.

引用

页码：673 / 676

页数：4

共 20 条

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