The proliferative potential of the pilocytic astrocytoma: The relation between MIB-1 labeling and clinical and neuro-radiological follow-up

被引:36
作者
Dirven, CMF
Koudstaal, J
Mooij, JJA
Molenaar, WM
机构
[1] Free Univ Amsterdam Hosp, Dept Neurosurg, NL-1007 MB Amsterdam, Netherlands
[2] Univ Groningen Hosp, Dept Pathol, Groningen, Netherlands
[3] Univ Groningen Hosp, Dept Neurosurg, Groningen, Netherlands
关键词
pilocytic astrocytoma; proliferative potential; MIB-1; labeling; neuro-radiological; follow-up;
D O I
10.1023/A:1005905009449
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The proliferative potential of 39 pilocytic and 5 low grade astrocytomas was studied in relation to the Ki-67 activity as measured by the MIB-1 Labelings Index. The results were correlated to the biological behaviour of the tumor as measured by clinical and neuro-radiological (CT- or MRI-scans) follow-up of the patient. This study was undertaken to answer the question whether MIB-1 expression reflects differences in biological behaviour of these tumors, such as rapid progression of residual tumor or stable remaining tumor. MIB-1 LI values ranged from 0 to 19% in the group of pilocytic astrocytomas (mean 4,2%) and from 0 to 15% in the 5 low grade astrocytomas (mean 4,2%). All patients were operated and 23 of them had incomplete tumor resection as proven on postoperative neuro-imaging studies. Those 23 patients could be subdivided into two groups, one without progression of residual tumor during follow-up (n = 12) and the other with tumor progression (n = 11). mean MIB-1 LI in the group with 'quiescent' tumor tended to be lower than in the group with progressive tumor: 3,3% vs. 6,6%. Residual tumors which were negative for MIB-1 staining showed fewer progressions of residual tumor compared to those being positive for MIB-1 staining, however this difference was not significant (p = 0, 15, Fisher exact test). Tumor samples of a second operation of the same patient had lower MIB-1 LI values than those of the samples taken at first operation. The proliferating potential seemed to be decreased after part of the tumor was resected. Pilocytic astrocytomas with a negative MIB-1 LI are unlikely to show progression of residual tumor after partial resection. MIB-1 staining might be an additional tool in determining the frequency and duration of follow-up and in making decisions regarding further treatment of a patient operated for a pilocytic astrocytoma with residual tumor.
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页码:9 / 16
页数:8
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