Atg5 and Bcl-2 provide novel insights into the interplay between apoptosis and autophagy

被引:128
作者
Luo, S. [1 ]
Rubinsztein, D. C. [1 ]
机构
[1] Addenbrookes Hosp, Dept Med Genet, Med Res Inst, Cambridge CB2 2XY, England
基金
英国医学研究理事会; 英国惠康基金;
关键词
D O I
10.1038/sj.cdd.4402149
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:1247 / 1250
页数:5
相关论文
共 31 条
[21]   Yeast autophagosomes:: de novo formation of a membrane structure [J].
Noda, T ;
Suzuki, K ;
Ohsumi, Y .
TRENDS IN CELL BIOLOGY, 2002, 12 (05) :231-235
[22]   Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy [J].
Pattingre, S ;
Tassa, A ;
Qu, XP ;
Garuti, R ;
Liang, XH ;
Mizushima, N ;
Packer, M ;
Schneider, MD ;
Levine, B .
CELL, 2005, 122 (06) :927-939
[23]   Distinct classes of phosphatidylinositol 3′-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells [J].
Petiot, A ;
Ogier-Denis, E ;
Blommaart, EFC ;
Meijer, AJ ;
Codogno, P .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (02) :992-998
[24]   Essential roles of Atg5 and FADD in autophagic cell death - Dissection of autophagic cell death into vacuole formation and cell death [J].
Pyo, JO ;
Jang, MH ;
Kwon, YK ;
Lee, HJ ;
Jun, JIL ;
Woo, HN ;
Cho, DH ;
Choi, B ;
Lee, H ;
Kim, JH ;
Mizushima, N ;
Oshumi, Y ;
Jung, YK .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2005, 280 (21) :20722-20729
[25]   Rapamycin pre-treatment protects against apoptosis [J].
Ravikumar, B ;
Berger, Z ;
Vacher, C ;
O'Kane, CJ ;
Rubinsztein, DC .
HUMAN MOLECULAR GENETICS, 2006, 15 (07) :1209-1216
[26]   Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease [J].
Ravikumar, B ;
Vacher, C ;
Berger, Z ;
Davies, JE ;
Luo, SQ ;
Oroz, LG ;
Scaravilli, F ;
Easton, DF ;
Duden, R ;
O'Kane, CJ ;
Rubinsztein, DC .
NATURE GENETICS, 2004, 36 (06) :585-595
[27]   Autophagy and its possible roles in nervous system diseases, damage and repair [J].
Rubinszfein, David C. ;
DiFiglia, Marion ;
Heintz, Nathaniel ;
Nixon, Ralph A. ;
Qin, Zheng-Hong ;
Ravikumar, Brinda ;
Stefanis, Leonidas ;
Tolkovsy, Aviva .
AUTOPHAGY, 2005, 1 (01) :11-22
[28]   Bcl-2 down-regulation causes autophagy in a caspase-independent manner in human leukemic HL60 cells [J].
Saeki, K ;
Yuo, A ;
Okuma, E ;
Yazaki, Y ;
Susin, SA ;
Kroemer, G ;
Takaku, F .
CELL DEATH AND DIFFERENTIATION, 2000, 7 (12) :1263-1269
[29]   Lithium induces autophagy by inhibiting inositol monophosphatase [J].
Sarkar, S ;
Floto, RA ;
Berger, Z ;
Imarisio, S ;
Cordenier, A ;
Pasco, M ;
Cook, LJ ;
Rubinsztein, DC .
JOURNAL OF CELL BIOLOGY, 2005, 170 (07) :1101-1111
[30]   Phoxy lipids: Revealing PX domains as phosphoinositide binding modules [J].
Wishart, MJ ;
Taylor, GS ;
Dixon, JE .
CELL, 2001, 105 (07) :817-820