total synthesis;
alkaloids;
pyrroles;
hydrogenation;
D O I:
10.1016/j.tetlet.2004.12.066
中图分类号:
O62 [有机化学];
学科分类号:
070303 ;
081704 ;
摘要:
Addition of a propargyl Grignard reagent to 3,4-dihydro-6,7-dimethoxyisoquinoline, silver(I)-promoted oxidative cyclization, and chemoselective hydrogenation of the pyrrole ring provide a simple three-step route to the antitumor active pyrrolo[2,1-a]isoquinoline alkaloid (+/-)-crispine A. (C) 2004 Elsevier Ltd. All rights reserved.