Total synthesis of the antitumor active pyrrolo[2,1-α]isoquinoline alkaloid (±)-crispine A

被引:117
作者
Knölker, HJ [1 ]
Agarwal, S [1 ]
机构
[1] Tech Univ Dresden, Inst Organ Chem, D-01069 Dresden, Germany
关键词
total synthesis; alkaloids; pyrroles; hydrogenation;
D O I
10.1016/j.tetlet.2004.12.066
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
Addition of a propargyl Grignard reagent to 3,4-dihydro-6,7-dimethoxyisoquinoline, silver(I)-promoted oxidative cyclization, and chemoselective hydrogenation of the pyrrole ring provide a simple three-step route to the antitumor active pyrrolo[2,1-a]isoquinoline alkaloid (+/-)-crispine A. (C) 2004 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1173 / 1175
页数:3
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