The utility of immunohistochemical detection of DNA mismatch repair gene proteins

被引：94

作者：

Shia, J

Ellis, NA

Klimstra, DS

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Pathol, New York, NY 10021 USA

[2] Mem Sloan Kettering Canc Ctr, Dept Med, New York, NY 10021 USA

来源：

VIRCHOWS ARCHIV | 2004年 / 445卷 / 05期

关键词：

microsatellite instability; DNA mismatch repair gene proteins; immunohistochemistry;

D O I：

10.1007/s00428-004-1090-5

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Since the development of monoclonal antibodies against the MSH2 protein by Leach et al. in 1996, a series of investigations has been undertaken to determine the utility of immunohistochemical detection of DNA mismatch repair (MMR) gene proteins in the identification of hereditary or sporadic colorectal tumors with microsatellite instability. These studies, however, have been performed with different aims and on different patient populations. Interpretation of these immunohistochemical data relies on a thorough understanding of the biological and technical factors that affect the detection of MMR proteins. In this review, we analyze the data from the published research studies, pointing out the various factors affecting immunohistochemical detection of MMR proteins and projecting the utility of immunohistochemistry in different clinical settings.

引用

收藏

页码：431 / 441

页数：11

相关论文

共 67 条

[51]

Rigau V, 2003, ARCH PATHOL LAB MED, V127, P694

[52] Correlation of mismatch repair genes immunohistochemistry and microsatellite instability status in HNPCC-associated tumours [J].

Ruszkiewicz, A ;

Bennett, G ;

Moore, J ;

Manavis, J ;

Rudzki, B ;

Shen, L ;

Suthers, G .

PATHOLOGY, 2002, 34 (06) :541-547

[53] Microsatellite instability and hMLH1 and hMSH2 expression analysis in familial and sporadic colorectal cancer [J].

Salahshor, S ;

Koelble, K ;

Rubio, C ;

Lindblom, A .

LABORATORY INVESTIGATION, 2001, 81 (04) :535-541

[54] Mutations of hMLH1 and hMSH2 in patients with suspected hereditary nonpolyposis colorectal cancer:: Correlation with microsatellite instability and abnormalities of mismatch repair protein expression [J].

Scartozzi, M ;

Bianchi, F ;

Rosati, S ;

Galizia, E ;

Antolini, A ;

Loretelli, C ;

Piga, A ;

Bearzi, I ;

Cellerino, R ;

Porfiri, E .

JOURNAL OF CLINICAL ONCOLOGY, 2002, 20 (05) :1203-1208

[55] Value of histopathology in predicting microsatellite instability in hereditary nonpolyposis colorectal cancer and sporadic colorectal cancer [J].

Shia, J ;

Ellis, NA ;

Paty, PB ;

Nash, GM ;

Qin, J ;

Offit, K ;

Zhang, XM ;

Markowitz, AJ ;

Nafa, K ;

Guillem, JG ;

Wong, WD ;

Gerald, WL ;

Klimstra, DS .

AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2003, 27 (11) :1407-1417

[56] Immunohistochemistry for MSH2 and MHL1: a method for identifying mismatch repair deficient colorectal cancer [J].

Stone, JG ;

Robertson, D ;

Houlston, RS .

JOURNAL OF CLINICAL PATHOLOGY, 2001, 54 (06) :484-487

[57] Efficient detection of hereditary nonpolyposis colorectal cancer gene carriers by screening for tumor microsatellite instability before germline genetic testing [J].

Terdiman, JP ;

Gum, JR ;

Conrad, PG ;

Miller, GA ;

Weinberg, V ;

Crawley, SC ;

Levin, TR ;

Reeves, C ;

Schmitt, A ;

Hepburn, M ;

Sleisenger, MH ;

Kim, YS .

GASTROENTEROLOGY, 2001, 120 (01) :21-30

[58]

Thibodeau SN, 1998, CANCER RES, V58, P1713

[59] Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability [J].

Umar, A ;

Boland, CR ;

Terdiman, JP ;

Syngal, S ;

de la Chapelle, A ;

Rüschoff, J ;

Fishel, R ;

Lindor, NM ;

Burgart, LJ ;

Hamelin, R ;

Hamilton, SR ;

Hiatt, RA ;

Jass, J ;

Lindblom, A ;

Lynch, HT ;

Peltomaki, P ;

Ramsey, SD ;

Rodriguez-Bigas, MA ;

Vasen, HFA ;

Hawk, ET ;

Barrett, JC ;

Freedman, AN ;

Srivastava, S .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (04) :261-268

[60]

van Rijnsoever M, 2003, CLIN CANCER RES, V9, P2898

← 1 2 3 4 5 6 7 →