Passive Immunization with LINGO-1 Polyclonal Antiserum Afforded Neuroprotection and Promoted Functional Recovery in a Rat Model of Spinal Cord Injury

被引：21

作者：

Lv, Jun ^{[1
]}

Xu, Ru-xiang ^{[1
]}

Jiang, Xiao-dan ^{[1
]}

Lu, Xin ^{[2
]}

Ke, Yi-quan ^{[1
]}

Cai, Ying-qian ^{[1
]}

Du, Mou-xuan ^{[1
]}

Hu, Changchen ^{[1
]}

Zou, Yu-xi ^{[1
]}

Qin, Ling-sha ^{[1
]}

Zeng, Yan-jun ^{[3
]}

机构：

[1] So Med Univ, Zhujiang Hosp, Neurosurg Inst Guangdong, Dept Neurosurg, Guangzhou 510282, Guangdong, Peoples R China

[2] So Med Univ, Zhujiang Hosp, Dept Endocrinol, Guangzhou 510282, Guangdong, Peoples R China

[3] Beijing Univ Technol, Biomech & Med Informat Inst, Beijing, Peoples R China

来源：

NEUROIMMUNOMODULATION | 2010年 / 17卷 / 04期

关键词：

LINGO-1; Passive immunization; Spinal cord injury; RhoA; Neuron apoptosis; Functional recovery; CENTRAL-NERVOUS-SYSTEM; AXONAL REGENERATION; INHIBITOR; RECEPTOR; RHO;

D O I：

10.1159/000290043

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

LINGO-1 (leucine-rich repeat and Ig domain-containing, Nogo receptor-interacting protein) is an important component of the NgR receptor complex involved in RhoA activation and axon regeneration. The authors report on passive immunization with LINGO-1 polyclonal antiserum, a therapeutic approach to overcome NgR-mediated growth inhibition after spinal cord injury (SCI). The intrathecally administered high-titer rabbit-derived antiserum can be detected around the injury site within a wide time window; it blocks LINGO-1 in vivo with high molecular specificity. In this animal model, passive immunization with LINGO-1 antiserum significantly decreased RhoA activation and increased neuronal survival. Adult rats immunized in this manner show recovery of certain hindlimb motor functions after dorsal hemisection of the spinal cord. Thus, passive immunotherapy with LINGO-1 polyclonal antiserum may represent a promising repair strategy following acute SCI. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：270 / 278

页数：9

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