Tumor-associated macrophages press the angiogenic switch in breast cancer

被引：355

作者：

Lin, Elaine Y.

Pollard, Jeffrey W.

机构：

[1] Albert Einstein Coll Med, Ctr Reprod Biol & Womens Hlth, Dept Dev & Mol Biol, Bronx, NY 10461 USA

[2] Albert Einstein Coll Med, Albert Einstein Canc Ctr, Dept Med, Div Oncol, Bronx, NY 10461 USA

来源：

CANCER RESEARCH | 2007年 / 67卷 / 11期

关键词：

D O I：

10.1158/0008-5472.CAN-07-0912

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The development of a supportive vasculature is essential for tumor progression. In a mouse model of breast cancer, we found that tumor-associated macrophages that are recruited to the tumor just before malignant conversion are essential for the angiogenic switch. These findings establish a causal linkage to explain well-documented clinical correlations between macrophages, microvessel density, and poor prognosis in breast tumors.

引用

页码：5064 / 5066

页数：3

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