Analysis of genes expressed at the infective larval stage validates utility of Litomosoides sigmodontis as a murine model for filarial vaccine development

被引：50

作者：

Allen, JE

Daub, J

Guiliano, D

McDonnell, A

Lizotte-Waniewski, M

Taylor, DW

Blaxter, M

机构：

[1] Univ Edinburgh, Inst Cell Anim & Populat Biol, Edinburgh EH9 3JT, Midlothian, Scotland

[2] Univ Edinburgh, Ctr Trop Vet Med, Roslin EH25 9RG, Midlothian, Scotland

[3] Smith Coll, Clark Sci Ctr, Northampton, MA 01063 USA

来源：

INFECTION AND IMMUNITY | 2000年 / 68卷 / 09期

关键词：

D O I：

10.1128/IAI.68.9.5454-5458.2000

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We used an expressed sequence tag approach to analyze genes expressed by the infective larvae of the rodent filarial parasite Litomosoides sigmodontis. One hundred fifty two new genes were identified, including several proposed as vaccine candidates in studies with human filarial parasites. Our findings have important implications for the use of L. sigmodontis as a model for filarial, infection.

引用

页码：5454 / 5458

页数：5

共 28 条

[1] Infection of BALB/c mice with the filarial nematode Litomosoides sigmodontis: Role of CD4(+) T cells in controlling larval development [J].