Synthetic studies on the HIJK-ring fragment of ciguatoxin

被引：35

作者：

Liu, TZ ^{[1
]}

Isobe, M ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Organ Chem Lab, Chikusa Ku, Nagoya, Aichi 4648601, Japan

来源：

TETRAHEDRON | 2000年 / 56卷 / 30期

关键词：

acetylene-biscobalthexacarbonyl; ciguatoxin; heteroconjugate addition; Sonogashira coupling; cyclization;

D O I：

10.1016/S0040-4020(00)00467-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Synthesis of the tetracyclic HIJK-ring fragment of ciguatoxin with high stereoselectivity has been achieved starting from a sugar derivative directed toward the synthesis of the right part of ciguatoxin. Sonogashira coupling of a vinyl iodide with an acetylene derivative, cobalt complex-mediated (seven- and eight-membered ring) cyclizations and a heteroconjugate addition reaction play important roles in the current research work. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：5391 / 5404

页数：14

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