Hippocampal region-specific contributions to memory performance in normal elderly

被引：95

作者：

Chen, Karren H. M. ^{[1
]}

Chuah, Lisa Y. M. ^{[1
]}

Sim, Sam K. Y. ^{[1
]}

Chee, Michael W. L. ^{[1
]}

机构：

[1] Duke NUS Grad Med Sch Singapore, Cognit Neurosci Lab, Neurosci & Behav Disorders Program, Singapore 169857, Singapore

来源：

BRAIN AND COGNITION | 2010年 / 72卷 / 03期

关键词：

Aging; Magnetic resonance imaging; Volumetry; Hippocampus; Maze-learning; Spatial memory; MILD COGNITIVE IMPAIRMENT; SPATIAL MEMORY; HEAD SIZE; FUNCTIONAL-DIFFERENTIATION; POSTERIOR HIPPOCAMPUS; LEARNING EFFICIENCY; EPISODIC MEMORY; SEX-DIFFERENCES; WORKING-MEMORY; ATROPHY;

D O I：

10.1016/j.bandc.2009.11.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

To investigate the relationship between regional hippocampal volume and memory in healthy elderly, 147 community-based volunteers, aged 55-83 years, were evaluated using magnetic resonance imaging, the Groton Maze Learning Test, Visual Reproduction and the Rey Auditory Verbal Learning Test. Hippocampal volumes were determined by interactive volumetry. We found greater age-related reduction in the volume of the hippocampal head relative to the tail. Right hippocampal tail volume correlated with spatial memory on the Groton Maze Learning Test while left hippocampal body volume was associated with delayed verbal memory. These associations were independent of age, sex, education and speed of processing and support the notion of functional differentiation along the long axis of the hippocampus. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：400 / 407

页数：8

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