Ferrocene-histidine conjugates:: N-ferrocenoyl-histidyl(imN-ferrocenoyl)methylester:: synthesis and structure

被引：17

作者：

Mandal, HS ^{[1
]}

Kkaatz, HB ^{[1
]}

机构：

[1] Univ Saskatchewan, Dept Chem, Saskatoon, SK S7N 5C9, Canada

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2003年 / 674卷 / 1-2期

基金：

加拿大自然科学与工程研究理事会;

关键词：

ferrocene; histidine; bioconjugate; amino acid; X-ray; electrochemistry;

D O I：

10.1016/S0022-328X(03)00182-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The preparation of the new ferrocenoyl histidyl conjugates N-Fc-His-OMe (2) and N-Fc-His(epsilon-N-Fc)-OMe (3) and of a simple ferrocenoyl imidazole conjugate Fc-Im (4) is reported together with their spectroscopic and electrochemical characterization. The electrochemistry of 3 exhibits two fully reversible one-electron. oxidations, which are due to the stepwise oxidation of the two ferrocenoyl groups. The crystal structure of 3 shows the difference in the chemical environment of the two Fc groups, one being attached to the alpha-N and one being attached to the epsilon-N of the imidazole of histidine. There is no discernible intermolecular interaction present in the crystal structure. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：32 / 37

页数：6

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