Limbic encephalitis: A cause of temporal lobe epilepsy with onset in adult life

被引：104

作者：

Bien, Christian G. ^{[1
]}

Elger, Christian E. ^{[1
]}

机构：

[1] Univ Bonn, Dept Epileptol, D-53105 Bonn, Germany

来源：

EPILEPSY & BEHAVIOR | 2007年 / 10卷 / 04期

关键词：

limbic encephalitis; adult-onset epilepsy; autoantibodies; paraneoplastic neurological syndromes; immunotherapy; memory deficits; mood disorders;

D O I：

10.1016/j.yebeh.2007.03.011

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Limbic encephalitis (LE) was described in the 1960s as a clinical-pathological syndrome in adults. Initially, the paraneoplastic form was the center of interest. An increasing number of diagnostically valuable autoantibodies in patients' sera (and cerebrospinal fluid) have been identified. Lately, the impact of non-paraneoplastic LE cases has been acknowledged. In the serum of some of these patients, antibodies against voltage-dependent potassium channels (VGKC antibodies) have been detected. The characteristic MRI course of LE patients has recently been described in detail: hippocampal swelling and T2/FLAIR signal increase are early findings. After a few months, the swelling regresses, followed by hippocampal atrophy with continuous signal increase. A general consensus on formal diagnostic criteria for all LE subsyndromes has not yet been reached. This article proposes such diagnostic criteria and formulates suggestions for treatment. (C) 2007 Elsevier Inc. All rights reserved.

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收藏

页码：529 / 538

页数：10

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