A randomized, double blind study in young healthy adults comparing cell mediated and humoral immune responses induced by influenza ISCOM™ vaccines and conventional vaccines

被引:112
作者
Rimmelzwaan, GF
Nieuwkoop, N
Brandenburg, A
Sutter, G
Beyer, WEP
Maher, D
Bates, J
Osterhaus, ADME
机构
[1] Erasmus Univ, Inst Virol, NL-3000 DR Rotterdam, Netherlands
[2] CSL Ltd, Parkville, Vic 3052, Australia
[3] CSL Ltd, Neuherberg, Germany
[4] GSF, Res Ctr, Inst Mol Virol, Neuherberg, Germany
关键词
CTL; ISCOM (TM); influenza; vaccine;
D O I
10.1016/S0264-410X(00)00310-8
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Although current influenza vaccines have been shown to reduce influenza-related morbidity and mortality, there is a desire to develop more efficacious products. Vaccines which can induce CD8(+) cytotoxic T cell (CTL) responses in addition to strong antibody responses may be more effective in preventing disease since it has been demonstrated that CTL contribute to protective immunity, even against drift variants of influenza A viruses. The immunogenicity of two types of experimental influenza vaccines, which were based on immune stimulating complexes (ISCOM(TM)), were evaluated and compared with a conventional non-adjuvanted inactivated split virion vaccine, after immunization of human volunteers. In this randomized, double blind study, it was shown that the ISCOM(TM) vaccines altered the kinetics of the serum antibody response, resulting in more rapid titer rises against the vaccine strains. This accelerated antibody response coincided with enhanced in vitro proliferative T cell responses, which were observed shortly after vaccination. In addition, CTL responses were observed in a higher proportion of the vaccinees receiving an ISCOM(TM) vaccine, than in vaccinees receiving the conventional influenza vaccine. (C) 2000 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:1180 / 1187
页数:8
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