Rapid decomposition of peroxynitrite by manganese porphyrin-antioxidant redox couples

被引：61

作者：

Lee, JB ^{[1
]}

Hunt, JA ^{[1
]}

Groves, JT ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT CHEM,PRINCETON,NJ 08544

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 22期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(97)10109-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mn(III)TMPyP reacts rapidly with the toxic oxidant peroxynitrite (ONOO-) to generate an oxoMn(IV) species, but Mn(III)TMPyP is not catalytic for ONOO- decomposition due to the slow reduction of oxoMn(IV) back to the Mn(III) oxidation state. However, when redox-coupled, with biological antioxidants that efficiently reduce oxoMn(IV), Mn(III)TMPyP is transformed into an efficient ''peroxynitrite reductase.'' (C) 1997 Elsevier Science Ltd.

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页码：2913 / 2918

页数：6

相关论文

共 29 条

[1] THE KINETICS OF THE OXIDATION OF L-ASCORBIC-ACID BY PEROXYNITRITE [J].

BARTLETT, D ;

CHURCH, DF ;

BOUNDS, PL ;

KOPPENOL, WH .

FREE RADICAL BIOLOGY AND MEDICINE, 1995, 18 (01) :85-92

[2]

Beckman JS, 1996, AM J PHYSIOL-CELL PH, V271, pC1424

[3] KINETICS OF SUPEROXIDE DISMUTASE-CATALYZED AND IRON-CATALYZED NITRATION OF PHENOLICS BY PEROXYNITRITE [J].

BECKMAN, JS ;

ISCHIROPOULOS, H ;

ZHU, L ;

VANDERWOERD, M ;

SMITH, C ;

CHEN, J ;

HARRISON, J ;

MARTIN, JC ;

TSAI, M .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1992, 298 (02) :438-445

[4] A HIGHLY SENSITIVE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY METHOD FOR THE ESTIMATION OF ASCORBIC AND DEHYDROASCORBIC ACID IN TISSUES, BIOLOGICAL-FLUIDS, AND FOODS [J].

BEHRENS, WA ;

MADERE, R .

ANALYTICAL BIOCHEMISTRY, 1987, 165 (01) :102-107

[5] THE PECKING ORDER OF FREE-RADICALS AND ANTIOXIDANTS - LIPID-PEROXIDATION, ALPHA-TOCOPHEROL, AND ASCORBATE [J].

BUETTNER, GR .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1993, 300 (02) :535-543

[6]

BURTON GW, 1990, ANNU REV NUTR, V10, P357, DOI 10.1146/annurev.nutr.10.1.357

[7]

CASTRO L, 1994, J BIOL CHEM, V269, P29409

[8]

FAULKNER KM, 1994, J BIOL CHEM, V269, P23471

[9]

FLORIS R, 1993, EUR J BIOCHEM, V215, P767, DOI 10.1111/j.1432-1033.1993.tb18091.x

[10] PEROXYNITRITE-INDUCED DNA STRAND SCISSION MEDIATED BY A MANGANESE PORPHYRIN [J].

GROVES, JT ;

MARLA, SS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (37) :9578-9579