Rapid decomposition of peroxynitrite by manganese porphyrin-antioxidant redox couples

被引：61

作者：

Lee, JB ^{[1
]}

Hunt, JA ^{[1
]}

Groves, JT ^{[1
]}

机构：

[1] PRINCETON UNIV,DEPT CHEM,PRINCETON,NJ 08544

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 22期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(97)10109-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Mn(III)TMPyP reacts rapidly with the toxic oxidant peroxynitrite (ONOO-) to generate an oxoMn(IV) species, but Mn(III)TMPyP is not catalytic for ONOO- decomposition due to the slow reduction of oxoMn(IV) back to the Mn(III) oxidation state. However, when redox-coupled, with biological antioxidants that efficiently reduce oxoMn(IV), Mn(III)TMPyP is transformed into an efficient ''peroxynitrite reductase.'' (C) 1997 Elsevier Science Ltd.

引用

页码：2913 / 2918

页数：6

共 29 条

[11] Detection and characterization of an oxomanganese(V) porphyrin complex by rapid-mixing stopped-flow spectrophotometry [J].