Nomenclature- and Database-Compatible Names for the Two Ebola Virus Variants that Emerged in Guinea and the Democratic Republic of the Congo in 2014

被引：69

作者：

Kuhn, Jens H. ^{[1
]}

Andersen, Kristian G. ^{[2
]}

Baize, Sylvain ^{[3
,4
]}

Bao, Yiming ^{[5
]}

Bavari, Sina ^{[6
]}

Berthet, Nicolas ^{[7
]}

Blinkova, Olga ^{[5
]}

Brister, J. Rodney ^{[5
]}

Clawson, Anna N. ^{[1
]}

Fair, Joseph ^{[8
]}

Gabriel, Martin ^{[9
,10
]}

Garry, Robert F. ^{[11
]}

Gire, Stephen K. ^{[2
]}

Goba, Augustine ^{[12
]}

Gonzalez, Jean-Paul ^{[13
]}

Guenther, Stephan ^{[9
,10
]}

Happi, Christian T. ^{[14
,15
]}

Jahrling, Peter B. ^{[1
]}

Kapetshi, Jimmy

Kobinger, Gary ^{[16
]}

Kugelman, Jeffrey R. ^{[6
]}

Leroy, Eric M. ^{[7
]}

Maganga, Gael Darren ^{[7
]}

Mbala, Placide K.

Moses, Lina M. ^{[11
]}

Muyembe-Tamfum, Jean-Jacques

N'Faly, Magassouba ^{[17
]}

Nichol, Stuart T. ^{[18
]}

Omilabu, Sunday A. ^{[19
]}

Palacios, Gustavo ^{[6
]}

Park, Daniel J. ^{[20
]}

Paweska, Janusz T. ^{[21
]}

Radoshitzky, Sheli R. ^{[6
]}

Rossi, Cynthia A. ^{[6
]}

Sabeti, Pardis C. ^{[2
]}

Schieffelin, John S. ^{[11
]}

Schoepp, Randal J. ^{[6
]}

Sealfon, Rachel ^{[22
]}

Swanepoel, Robert ^{[23
]}

Towner, Jonathan S. ^{[18
]}

Wada, Jiro ^{[1
]}

Wauquier, Nadia ^{[13
]}

Yozwiak, Nathan L. ^{[2
]}

Formenty, Pierre ^{[24
]}

机构：

[1] NIAID, Integrated Res Facil Ft Detrick, NIH, Frederick, MD 21702 USA

[2] Harvard Univ, FAS Ctr Syst Biol, Cambridge, MA 02138 USA

[3] Inst Pasteur, Unite Biol Infect Virales Emergentes, Lyon, France

[4] Univ Lyon 1, CNRS, Ecole Normale Super Lyon, CIRI,INSERM,U1111,UMR5308, F-69365 Lyon, France

[5] NIH, Informat Engn Branch, Natl Ctr Biotechnol Informat, Natl Lib Med, Bethesda, MD 20894 USA

[6] US Army, Med Res Inst Infect Dis, Frederick, MD 21702 USA

[7] Ctr Int Rech Med Franceville, Franceville, Gabon

[8] Fdn Merieux, Washington, DC 20036 USA

[9] WHO, Bernhard Nocht Inst Trop Med, Collaborating Ctr Arbovirus & Hemorrhag Fever Ref, D-20259 Hamburg, Germany

[10] German Ctr Infect Res DZIF, D-20259 Hamburg, Germany

[11] Tulane Univ, Sch Med, New Orleans, LA 70112 USA

[12] Kenema Govt Hosp, Kenema, Sierra Leone

[13] Metabiota Inc, San Francisco, CA 94104 USA

[14] Redeemers Univ, Coll Nat Sci, Dept Biol Sci, Mowe, Ogun State, Nigeria

[15] Redeemers Univ, African Ctr Excellence Genom Infect Dis, Mowe, Ogun State, Nigeria

[16] Publ Hlth Agcy Canada, Natl Microbiol Lab, Special Pathogens Program, Winnipeg, MB R3E 3R2, Canada

[17] Univ Gamal Abdel Nasser de Conakry, Lab Fievres Hemorrag Guinee, Hop Natl Donka, Serv Malad Infect & Trop, Conakry, Guinea

[18] Ctr Dis Control & Prevent, Natl Ctr Emerging & Zoonot Infect Dis, Div High Consequence Pathogens & Pathol, Viral Special Pathogens Branch, Atlanta, GA 30333 USA

[19] Univ Lagos, Coll Med, Dept Med Microbiol & Parasitol, Lagos, Nigeria

[20] Broad Inst, Cambridge, MA 02142 USA

[21] Natl Hlth Lab Serv, Natl Inst Communicable Dis, Ctr Emerging & Zoonot Dis, ZA-2192 Sandringham Johannesburg, Gauteng, South Africa

[22] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02139 USA

[23] Univ Pretoria, Zoonoses Res Unit, ZA-0028 Pretoria, South Africa

[24] WHO, CH-1211 Geneva, Switzerland

来源：

VIRUSES-BASEL | 2014年 / 6卷 / 11期

关键词：

Ebola; Ebola virus; ebolavirus; filovirid; Filoviridae; filovirus; genome annotation; Lomela; Lokolia; Makona; mononegavirad; Mononegavirales; mononegavirus; virus classification; virus isolate; virus nomenclature; virus strain; virus taxonomy; virus variant; INTERNATIONAL COMMITTEE; TAXONOMIC PROPOSALS; RATIFICATION VOTE;

D O I：

10.3390/v6114760

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In 2014, Ebola virus (EBOV) was identified as the etiological agent of a large and still expanding outbreak of Ebola virus disease (EVD) in West Africa and a much more confined EVD outbreak in Middle Africa. Epidemiological and evolutionary analyses confirmed that all cases of both outbreaks are connected to a single introduction each of EBOV into human populations and that both outbreaks are not directly connected. Coding-complete genomic sequence analyses of isolates revealed that the two outbreaks were caused by two novel EBOV variants, and initial clinical observations suggest that neither of them should be considered strains. Here we present consensus decisions on naming for both variants (West Africa: "Makona", Middle Africa: "Lomela") and provide database-compatible full, shortened, and abbreviated names that are in line with recently established filovirus sub-species nomenclatures.

引用

页码：4760 / 4799

页数：40

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