Branching out to gain control:: how the pre-TCR is linked to multiple functions

被引：102

作者：

Kruisbeek, AM

Haks, MC

Carleton, M

Michie, AM

Zúñiga-Pflücker, JC

Wiest, DL

机构：

[1] Netherlands Canc Inst, Div Immunol, NL-1066 CX Amsterdam, Netherlands

[2] Fox Chase Canc Ctr, Philadelphia, PA 19111 USA

[3] Univ Toronto, Dept Immunol, Toronto, ON M5S 1A8, Canada

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 12期

基金：

英国医学研究理事会; 加拿大健康研究院; 美国国家卫生研究院;

关键词：

D O I：

10.1016/S0167-5699(00)01744-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

How is signaling specificity achieved by the pre-TCR during selection of T-cell fate? Like the TCR, this receptor controls many functions, and recent studies define which pathways couple the pre-TCR to the molecular events controlling survival, proliferation, allelic exclusion at the TCR beta locus, and further differentiation.

引用

收藏

页码：637 / 644

页数：8

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