MCQTL: multi-allelic QTL mapping in multi-cross design

被引：82

作者：

Jourjon, MF ^{[1
]}

Jasson, S ^{[1
]}

Marcel, J ^{[1
]}

Ngom, B ^{[1
]}

Mangin, B ^{[1
]}

机构：

[1] INRA, Unite Biometrie & Intelligence Artificielle, F-31326 Castanet Tolosan, France

来源：

BIOINFORMATICS | 2005年 / 21卷 / 01期

关键词：

D O I：

10.1093/bioinformatics/bth481

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The aim of the MCQTL software package is to perform QTL mapping in multi-cross designs. It allows the analysis of the usual populations derived from inbred lines and can link the families by assuming that the QTL locations are the same in all of them. Moreover, a diallel modelling of the QTL genotypic effects is allowed in multiple related families. The implemented model is a linear regression model. A composite interval mapping and an iterative QTL mapping are implemented to deal with multiple QTL models. Marker cofactor selections by forward or backward stepwise methods are implemented as well as computation of threshold test value by permutation.

引用

页码：128 / 130

页数：3

共 18 条

[1] BioMercator: integrating genetic maps and QTL towards discovery of candidate genes
Arcade, A
Labourdette, A
Falque, M
Mangin, B
Chardon, F
Charcosset, A
Joets, J
[J]. BIOINFORMATICS, 2004, 20 (14) : 2324 - 2326
[2] BINK MCA, 2004, P PAG 12 SAN DIEG CA
[3] R/qtl: QTL mapping in experimental crosses
Broman, KW
Wu, H
Sen, S
Churchill, GA
[J]. BIOINFORMATICS, 2003, 19 (07) : 889 - 890
[4] CHARCOSSET A, 2001, C INRA, V96
[5] CHURCHILL GA, 1994, GENETICS, V138, P963
[6] A SIMPLE REGRESSION METHOD FOR MAPPING QUANTITATIVE TRAIT LOCI IN LINE CROSSES USING FLANKING MARKERS
HALEY, CS
KNOTT, SA
[J]. HEREDITY, 1992, 69 : 315 - 324
[7] Multiple cross mapping (MCM) markedly improves the localization of a QTL for ethanol-induced activation
Hitzemann, R
Malmanger, B
Cooper, S
Coulombe, S
Reed, C
Demarest, K
Koyner, J
Cipp, L
Flint, J
Talbot, C
Rademacher, B
Buck, K
McCaughran, J
[J]. GENES BRAIN AND BEHAVIOR, 2002, 1 (04) : 214 - 222
[8] Estimating allelic number and identity in state of QTLs in interconnected families
Jannink, JL
Wu, XL
[J]. GENETICAL RESEARCH, 2003, 81 (02) : 133 - 144
[9] Quantitative trait loci mapping in dairy cattle: review and meta-analysis
Khatkar, MS
Thomson, PC
Tammen, I
Raadsma, HW
[J]. GENETICS SELECTION EVOLUTION, 2004, 36 (02) : 163 - 190
[10] Lincoln S, 1993, CONSTRUCTING GENETIC

← 1 2 →