Forensic DNA analysis on microfluidic devices: A review

被引：137

作者：

Horsman, Katie M.

Bienvenue, Joan M.

Blasier, Kiev R.

Landers, James P.

机构：

[1] Univ Virginia, Dept Chem, Charlottesville, VA 22904 USA

[2] Univ Virginia, Sch Med, Dept Pathol, Charlottesville, VA 22904 USA

[3] Univ Virginia, Dept Mech Engn, Charlottesville, VA 22904 USA

来源：

JOURNAL OF FORENSIC SCIENCES | 2007年 / 52卷 / 04期

关键词：

forensic science; DNA typing; microfluidics; microchip technology;

D O I：

10.1111/j.1556-4029.2007.00468.x

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

The advent of microfluidic technology for genetic analysis has begun to impact forensic science. Recent advances in microfluidic separation of short-tandem-repeat (STR) fragments has provided unprecedented potential for improving speed and efficiency of DNA typing. In addition, the analytical processes associated with sample preparation--which include cell sorting, DNA extraction, DNA quantitation, and DNA amplification-can all be integrated with the STR separation in a seamless manner. The current state of these microfluidic methods as well as their advantages and potential shortcomings are detailed. Recent advances in microfluidic device technology, as they pertain to forensic DNA typing, are discussed with a focus on the forensic community.

引用

页码：784 / 799

页数：16

共 132 条

[41] Microfluidic assays of acetylcholinesterase inhibitors [J].