The Pauson-Khand reaction: the catalytic age is here!

被引:353
作者
Gibson, SE [1 ]
Stevenazzi, A [1 ]
机构
[1] Kings Coll London, Dept Chem, Danielle Chair Chem, London WC2 R2LS, England
关键词
cyclization; enones; homogeneous catalysis; Pauson-Khand reaction; transition-metal complexes;
D O I
10.1002/anie.200200547
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
As a consequence of growing environmental awareness, it is now inappropriate to design a synthetic metal-mediated transformation that involves a noncatalytic use of toxic and expensive transition-metal species. One of the earliest examples of such a metal-mediated transformation is the Pauson-Khand reaction, a [2+2+1] cyclocarbonylation that generates a cyclopentenone. Despite the early descriptions by Pauson and co-workers of catalytic versions of the reaction with octacarbonyldicobalt(O), applications of the Pauson-Khand reaction have to date almost exclusively used approaches that involve stoichiometric quantities of cobalt-carbonyl complexes. In the last decade, and, most markedly, in the last two to three years, however, there have been many exciting and novel developments in the catalytic Pauson-Khand reaction. Furthermore, asymmetric catalysis of the Pauson-Khand reaction has been shown to be a viable process. In view of the impressive developments in Pauson-Khand catalysis in the last two to three years, we present a comprehensive and critical coverage of the catalytic Pauson-Khand reaction that is designed to facilitate its application and to point to exciting future developments.
引用
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页码:1800 / 1810
页数:11
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