Triad 1 induces apoptosis by p53 activation

被引：15

作者：

Jung, Jin Hyuk ^{[1
]}

Lee, Sun-Mi ^{[1
]}

Bae, Seunghee ^{[1
]}

Lee, Su-Jae ^{[2
]}

Park, In-Chul ^{[3
]}

Jin, Young-Woo ^{[4
]}

Lee, Jae Ho ^{[1
]}

An, Sungkwan ^{[1
,5
]}

机构：

[1] Konkuk Univ, Funct Genome Res Inst, Seoul 143701, South Korea

[2] Hanyang Univ, Dept Chem, Seoul 133791, South Korea

[3] Korea Inst Radiol & Med Sci, Lab Funct Genom, Seoul 139706, South Korea

[4] KHNP, Radiat Hlth Res Inst, Div Radiat Effect Res, Seoul 132703, South Korea

[5] Konkuk Univ, Venture Business Supporting Ctr, LIFEnGENE Inc, Seoul 143701, South Korea

来源：

FEBS LETTERS | 2010年 / 584卷 / 08期

关键词：

Triad; 1; Gfi-1; Apoptosis; p53; RING finger; UBIQUITIN LIGASE; RETINOIC ACID; DEGRADATION; CELLS; STABILIZATION; EXPRESSION; PATHWAY; GROWTH; DEATH; MDM2;

D O I：

10.1016/j.febslet.2010.03.011

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Triad 1 (2 RING [ really interesting new gene] fingers and DRIL [double RING finger linked] 1) is an E3 ligase that induces apoptosis and clonogenic inhibition in myeloid cells through Gfi-1 stabilization. Here we demonstrate that Triad 1 induces apoptosis in several cancer cell lines including MCF7, A549, U2OS, and HCT 116 p53(+/+) cells via its RING ligase activity. Interestingly, in these cancer cells, Triad 1-induced apoptosis is not mediated by Gfi-1 stabilization but is instead p53-dependent. Moreover, Triad 1 promotes transactivation of p53. These results suggest that Triad 1 can induce apoptosis through its ligase activity via p53 activation. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1565 / 1570

页数：6

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