Protein turnover and differentiation in Leishmania

被引：95

作者：

Besteiro, Sebastien

Williams, Roderick A. M.

Coombs, Graham H.

Mottram, Jeremy C.

机构：

[1] Univ Glasgow, Inst Biomed & Life Sci, Wellcome Ctr Mol Parasitol, Glasgow G12 8TA, Lanark, Scotland

[2] Univ Glasgow, Inst Biomed & Life Sci, Div Infect & Immun, Glasgow G12 8TA, Lanark, Scotland

[3] Univ Strathclyde, Strathclyde Inst Pharm & Biomed Sci, Glasgow G4 0NR, Lanark, Scotland

来源：

INTERNATIONAL JOURNAL FOR PARASITOLOGY | 2007年 / 37卷 / 10期

基金：

英国医学研究理事会;

关键词：

Leishmania; differentiation; protease; peptidase; genome;

D O I：

10.1016/j.ijpara.2007.03.008

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

Leishmania occurs in several developmental forms and thus undergoes complex cell differentiation events during its life-cycle. Those are required to allow the parasite to adapt to the different environmental conditions. The sequencing of the genome of L. major has facilitated the identification of the parasite's vast arsenal of proteolytic enzymes, a few of which have already been carefully studied and found to be important for the development and virulence of the parasite. This review focuses on these peptidases and their role in the cellular differentiation of Leishmania through their key involvement in a variety of degradative pathways in the lysosomal and autophagy networks. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.

引用

页码：1063 / 1075

页数：13

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