Controlled release of terbinafine hydrochloride from pH sensitive poly(acrylamide/maleic acid) hydrogels

被引：83

作者：

Sen, M ^{[1
]}

Uzun, C ^{[1
]}

Güven, O ^{[1
]}

机构：

[1] Hacettepe Univ, Dept Chem, TR-06532 Ankara, Turkey

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2000年 / 203卷 / 1-2期

关键词：

terbinafine hydrochloride; poly(acrylamide/maleic acid); hydrogel; pH sensitive;

D O I：

10.1016/S0378-5173(00)00449-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Adsorption and controlled release of terbinafine hydrochloride (TER-HCl) to and from pH sensitive poly(acrylamide/maleic acid) (P(AAm/MA)) hydrogels were investigated. P(AAm/MA) hydrogels were prepared by irradiating the ternary mixtures of AAm/MA/and water by gamma-rays at ambient temperature. Antifungal drug, TER-HCl containing hydrogels, at different drug to polymer ratios, was prepared by direct adsorption method. The influence of MA content in the gel on the adsorption capacities of hydrogel and the effect of pH on the releasing behavior of TER-HCl from gel matrix were investigated. Terbinafine adsorption capacity of hydrogels are found to increase from 2 to 38 mg TER-HCl per g dry gel with increasing amount of MA in the gel system. In vitro drug release studies in different buffer solutions show that the basic parameters affecting the drug release behavior of hydrogel are the pH of the solution and MA content of hydrogel. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：149 / 157

页数：9

共 23 条

[1] The effect of external stimuli on the Bovine Serum Albumin adsorption capacity of poly(acrylamide/maleic acid) hydrogels prepared by gamma rays [J].