The clinical significance of c-myc oncogene expression in melanomas of the scalp

被引：14

作者：

Chana, JS ^{[1
]}

Grover, R

Wilson, GD

Hudson, DA

Forders, M

Sanders, R

Grobbelaar, AO

机构：

[1] Mt Vernon Hosp, RAFT Inst Plast Surg, Northwood HA6 2RN, Middx, England

[2] Mt Vernon Hosp, Canc Res Trust, Gray Lab, Northwood HA6 2RN, Middx, England

[3] Groote Schuur Hosp, Dept Plast Surg, ZA-7925 Cape Town, South Africa

[4] Groote Schuur Hosp, Dept Histopathol, ZA-7925 Cape Town, South Africa

来源：

BRITISH JOURNAL OF PLASTIC SURGERY | 1998年 / 51卷 / 03期

关键词：

D O I：

10.1054/bjps.1997.0233

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Melanomas of the scalp are rare and have a poorer prognosis than melanomas arising at other cutaneous sites. In order to study the biology of this disease, the activity of the c-myc oncogene was studied in tumours from 25 patients with scalp melanoma using the technique of flow cytometry. Survival analysis revealed that stratification of patients according to oncogene activity provided a prognostic marker with shorter overall survival(log rank test, chi(2) = 3.9, P = 0.05) in tumours with high nuclear c-myc oncoprotein positivity. These results support our previous studies of the prognostic value of c-myc expression in melanoma and suggest that estimation of c-myc oncoprotein may be of clinical significance in identifying high risk patients.

引用

页码：191 / 194

页数：4