SERPINA3 (aka alpha-1-antichymotrypsin)

被引：124

作者：

Baker, Crystal ^{[1
]}

Belbin, Olivia ^{[1
]}

Kalsheker, Noor ^{[1
]}

Morgan, Kevin ^{[1
]}

机构：

[1] Univ Nottingham Hosp, Queens Med Ctr, Inst Genet, Div Clin Chem Mol Med Sci, Nottingham NG7 2UH, England

来源：

FRONTIERS IN BIOSCIENCE | 2007年 / 12卷

关键词：

serpin; alpha-1; antichymotrypsin; nervous system; ACT gene; single nucleotide polymorphism; SNP; Alzheimer's disease; review;

D O I：

10.2741/2275

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances in proteomic, transcriptomic and genomic technologies have revealed much about the ACT protein and gene. In this review, we summarize our current understanding of the structure and potential physiological roles of the ACT protein, catalogue the regulatory elements that have been implicated in expression of the ACT gene, describe its tissue-specific expression and list the single nucleotide polymorphisms (SNPs) within the gene that track ACT variability. The ACT gene has been implicated in a number of complex human disorders and its potential involvement as a risk factor for Alzheimer's disease has been the subject of intensive research. However, due to previous limitations in methodologies and inadequate sample numbers the data has been conflicting with many studies failing to be replicated. In this regard, we highlight some potential approaches, which may prove to be beneficial in future studies.

引用

页码：2821 / 2835

页数：15

共 105 条

[1] IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].