Selective amine recognition: Development of a chemosensor for dopamine and norepinephrine

被引：173

作者：

Secor, KE ^{[1
]}

Glass, TE ^{[1
]}

机构：

[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 21期

关键词：

D O I：

10.1021/ol048625f

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A boronic acid-containing coumarin aldehyde was designed and synthesized. The sensor binds to catecholamines such as dopamine and norepinephrine by forming an iminium ion with the amine as well as a boronate ester with the catechol. An internal hydrogen bond produces a colorimetric response to these analytes with good selectivity for catecholamines over simple amines. The fluorescence of the sensor is quenched by the catechol.

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页码：3727 / 3730

页数：4

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