Mathematical models of action potentials in the periphery and center of the rabbit sinoatrial node

被引:287
作者
Zhang, H
Holden, AV
Kodama, I
Honjo, H
Lei, M
Varghese, T
Boyett, MR [1 ]
机构
[1] Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England
[2] Nagoya Univ, Environm Med Res Inst, Dept Circulat, Nagoya, Aichi 46401, Japan
[3] Nagoya Univ, Environm Med Res Inst, Dept Humoral Regulat, Nagoya, Aichi 46401, Japan
[4] Univ Minnesota, Inst Math & Applicat, Minneapolis, MN 55455 USA
来源
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY | 2000年 / 279卷 / 01期
关键词
heart; pacemaking; regional differences; computer modeling;
D O I
10.1152/ajpheart.2000.279.1.H397
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Mathematical models of the action potential in the periphery and center of the rabbit sinoatrial (SA) node have been developed on the basis of published experimental data. Simulated action potentials are consistent with those recorded experimentally: the model-generated peripheral action potential has a more negative takeoff potential, faster upstroke, more positive peak value, prominent phase 1 repolarization, greater amplitude, shorter duration, and more negative maximum diastolic potential than the model-generated central action potential. In addition, the model peripheral cell shows faster pacemaking. The models behave qualitatively the same as tissue from the periphery and center of the SA node in response to block of tetrodotoxin-sensitive Na+ current, L- and T-type Ca2+ currents, 4-aminopyridine-sensitive transient outward current, rapid and slow delayed rectifying K+ currents, and hyperpolarization-activated current. A one-dimensional model of a string of SA node tissue, incorporating regional heterogeneity, coupled to a string of atrial tissue has been constructed to simulate the behavior of the intact SA node. In the one-dimensional model, the spontaneous action potential initiated in the center propagates to the periphery at similar to 0.06 m/s and then into the atrial muscle at 0.62 m/s.
引用
收藏
页码:H397 / H421
页数:25
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