Effects of aldosterone on forearm vasculature in treated chronic heart failure

被引：17

作者：

Gunaruwan, P

Schmitt, M

Sharman, J

Lee, L

Struthers, A

Frenneaux, M ^{[1
]}

机构：

[1] Univ Birmingham, Sch Med, Dept Cardiovasc Med, Birmingham B15 2TH, W Midlands, England

[2] Ninewells Hosp, Sch Med, Dept Clin Pharmacol & Therapeut, Dundee DD1 9SY, Scotland

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 95卷 / 03期

关键词：

D O I：

10.1016/j.amjcard.2004.09.047

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gouge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF. (C) 2005 by Excerpta Medica Inc.

引用

收藏

页码：412 / 414

页数：3

相关论文

共 19 条

[11] Rapid nongenomic effects of aldosterone on human forearm vasculature [J].

Schmidt, BMW ;

Oehmer, S ;

Delles, C ;

Bratke, R ;

Schneider, MP ;

Klingbeil, A ;

Fleischmann, EH ;

Schmieder, RE .

HYPERTENSION, 2003, 42 (02) :156-160

[12] Assessment of venous capacitance. Radionuclide plethysmography: methodology and research applications [J].

Schmitt, M ;

Blackman, DJ ;

Middleton, GW ;

Cockcroft, JR ;

Frenneaux, MP .

BRITISH JOURNAL OF CLINICAL PHARMACOLOGY, 2002, 54 (06) :565-576

[13] Atrial natriuretic peptide regulates regional vascular volume and venous tone in humans [J].

Schmitt, M ;

Broadley, AJM ;

Nightingale, AK ;

Payne, N ;

Gunaruwan, P ;

Taylor, J ;

Lee, L ;

Cockcroft, J ;

Struthers, AD ;

Frenneaux, MP .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2003, 23 (10) :1833-1838

[14] Aldosterone-induced vasculopathy [J].

Struthers, AD .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 2004, 217 (1-2) :239-241

[15] PRODUCTION OF ALDOSTERONE IN ISOLATED RAT-BLOOD VESSELS [J].

TAKEDA, Y ;

MIYAMORI, I ;

YONEDA, T ;

IKI, K ;

HATAKEYAMA, H ;

BLAIR, IA ;

HSIEH, FY ;

TAKEDA, R .

HYPERTENSION, 1995, 25 (02) :170-173

[16] Rapid non-genomic effects of aldosterone on rodent vascular function [J].

Uhrenholt, TR ;

Schjerning, J ;

Rasmussen, LE ;

Hansen, PB ;

Norregaard, R ;

Jensen, BL ;

Skott, O .

ACTA PHYSIOLOGICA SCANDINAVICA, 2004, 181 (04) :415-419

[17] Rapid nongenomic effect of aldosterone on vasoconstriction [J].

Uhrenholt, TR ;

Jensen, BL ;

Skott, O .

HYPERTENSION, 2004, 43 (05) :E30-E30

[18] Rapid cardiovascular action of aldosterone in man [J].

Wehling, M ;

Spes, CH ;

Win, N ;

Janson, CP ;

Schmidt, BMW ;

Theisen, K ;

Christ, M .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1998, 83 (10) :3517-3522

[19] Aldosterone blunts the baroreflex response in man [J].

Yee, KM ;

Struthers, AD .

CLINICAL SCIENCE, 1998, 95 (06) :687-692