The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders

被引：356

作者：

Kilduff, TS

Peyron, C

机构：

[1] SRI Int, Mol Neurobiol Lab, Menlo Pk, CA 94025 USA

[2] Stanford Univ, Dept Biol Sci, Stanford, CA 94305 USA

[3] Stanford Univ, Sch Med, Dept Psychiat & Behav Sci, Ctr Narcolepsy, Stanford, CA 94305 USA

来源：

TRENDS IN NEUROSCIENCES | 2000年 / 23卷 / 08期

关键词：

D O I：

10.1016/S0166-2236(00)01594-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The molecules originally described as the hypocretins and subsequently as the orexins were initially implicated in the control of food intake. Recent observations implicate this newly-described neurotransmitter system in the sleep disorder narcolepsy and, potentially, in the regulation of normal sleep processes. This article reviews the research that led to the isolation of the hypocretin/orexin peptides, their receptors and the activity of these molecules as we currently understand them. A model is proposed in which the cells that make these peptides might be involved in arousal state control.

引用

页码：359 / 365

页数：7

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