A short path synthesis of [13C/15N] multilabeled pyrimidine nucleosides starting from glucopyranose nucleosides

被引：13

作者：

Lagoja, IM

Pochet, S

Boudou, V

Little, R

Lescrinier, E

Rozenski, J

Herdewijn, P

机构：

[1] Katholieke Univ Leuven, Rega Inst Med Res, Med Chem Lab, B-3000 Louvain, Belgium

[2] Inst Pasteur, F-75724 Paris, France

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 05期

关键词：

D O I：

10.1021/jo0205098

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of fully [C-13/N-15] labeled pyrimidine nucleosides has been achieved from C-13-glucose and labeled nucleobases. The reaction scheme leads directly to the protected nucleosides without the need for the inversion of configuration of C-3 of C-13-glucose. This was achieved by an oxitative ring-opening reaction removing the carbon with the wrong configuration.

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页码：1867 / 1871

页数：5

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