Glial and neuronal cell numbers and cytochrome oxidase activity in CA1 and CA3 during postnatal development and aging of the rat

被引：11

作者：

Cimadevilla, JM

Moreno, LMG

Pardo, HG ^{[1
]}

Zahonero, MC

Arias, JL

机构：

[1] Univ Oviedo, Fac Psicol, Psychobiol Lab, Oviedo 33003, Spain

[2] Univ Complutense Madrid, Dept Psychobiol, Madrid, Spain

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1997年 / 99卷 / 01期

关键词：

cell number; cytochrome oxidase; postnatal development; brain aging; hippocampus; rat;

D O I：

10.1016/S0047-6374(97)00090-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Stereological methods (neuron and glial cell numbers) and histochemical methods (cytochrome c oxidase) were used to study postnatal development and aging of the CA1 and CA3 hippocampal areas in male rats. No changes were observed in 10 mu m sections in the neuronal population of areas CA1 and CA3 in any of the groups (14 days, 21 days, adult-90 days and elderly-22 months). Statistical differences were found in the number of glial cells in both the CA1 and CA3 areas. An increase was observed in cytochrome oxidase (GO) activity in the CA1 area in the 14 day old rats compared to the other groups while in area CA3 this parameter increased in the 14 and 21 day old groups and the group of adult rats. No significant changes in CO activity were found in the elderly rats in both areas. These results are discussed in the light of those recorded in other areas of the limbic system. (C) 1997 Elsevier Science Ireland Ltd.

引用

页码：49 / 60

页数：12

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[11]

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[12] AGE-DEPENDENT ALTERATIONS IN HIPPOCAMPAL SYNAPTIC PLASTICITY - RELATION TO MEMORY DISORDERS [J].