Mucosal administration of flagellin induces innate immunity in the mouse lung

被引：104

作者：

Honko, AN ^{[1
]}

Mizel, SB ^{[1
]}

机构：

[1] Wake Forest Univ, Sch Med, Dept Microbiol & Immunol, Winston Salem, NC 27157 USA

来源：

INFECTION AND IMMUNITY | 2004年 / 72卷 / 11期

关键词：

D O I：

10.1128/IAI.72.11.6676-6679.2004

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nonsurgical intratracheal instillation of 1 mug of purified, recombinant flagellin in several strains of mice stimulated a transient innate immune response in the lung characterized by the infiltration of neutrophils and the rapid production of tumor necrosis factor alpha, interleukin 6, granulocyte colony-stimulating factor, and the chemokines keratinocyte-derived chemokine, MIP1alpha, and MIP-2.

引用

页码：6676 / 6679

页数：4

共 29 条

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