共 131 条
The budding yeast spindle pole body: Structure, duplication, and function
被引:222
作者:
Jaspersen, SL
[1
]
Winey, M
[1
]
机构:
[1] Univ Colorado, Dept Mol Cellular & Dev Biol, Boulder, CO 80309 USA
关键词:
microtubules;
mitotic spindle;
centrosome;
gamma-tubulin;
microtubule organizing center;
D O I:
10.1146/annurev.cellbio.20.022003.114106
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Nucleation of microtubules by eukaryotic microtubule organizing centers (MTOCs) is required for a variety of functions, including chromosome segregation during mitosis and meiosis, cytokinesis, fertilization, cellular morphogenesis, cell motility, and intracellular trafficking. Analysis of MTOCs from different organisms shows that the structure of these organelles is widely varied even though they all share the function of microtubule nucleation. Despite their morphological diversity, many components and regulators of MTOCs, as well as principles in their assembly, seem to be conserved. This review focuses on one of the best-characterized MTOCs, the budding yeast spindle pole body (SPB). We review what is known about its structure, protein composition, duplication, regulation, and functions. In addition, we discuss how studies of the yeast SPB have aided investigation of other MTOCs, most notably the centrosome of animal cells.
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页码:1 / 28
页数:28
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