Mechanics and imaging of single DNA molecules

被引：8

作者：

Hegner, M ^{[1
]}

Grange, W ^{[1
]}

机构：

[1] Univ Basel, Inst Phys, NCCR Nanoscale Sci, CH-4056 Basel, Switzerland

来源：

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY | 2002年 / 23卷 / 5-6期

关键词：

D O I：

10.1023/A:1023446103620

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We review recent experiments that have revealed mechanical properties of single DNA molecules using advanced manipulation and force sensing techniques (scanning force microscopy (SFM), optical or magnetic tweezers, microneedles). From such measurements, intrinsic relevant parameters (persistence length, stretch modulus) as well as their dependence on external parameters (non-physiological conditions, coating with binding agents or proteins) are obtained on a single-molecule level. In addition, imaging of DNA molecules using SFM is presented.

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页码：367 / 375

页数：9

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