学术探索
学术期刊
新闻热点
数据分析
智能评审

Feedback control of intercellular signalling in development

被引：394
作者：
Freeman, M [1 ]
机构：
[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England
来源：
NATURE | 2000年 / 408卷 / 6810期
关键词：
D O I：
10.1038/35042500
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The intercellular communication that regulates cell fate during animal development must be precisely controlled to avoid dangerous errors. How is this achieved? Recent work has highlighted the importance of positive and negative feedback loops in the dynamic regulation of developmental signalling. These feedback interactions can impart precision, robustness and versatility to intercellular signals. Feedback failure can cause disease.
引用
收藏
页码：313 / 319
页数：7
相关论文
共 85 条
  • [1] Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling
    Adams, TE
    Hansen, JA
    Starr, R
    Nicola, NA
    Hilton, DJ
    Billestrup, N
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (03) : 1285 - 1287
  • [2] The Drosophila smoothened gene encodes a seven-pass membrane protein, a putative receptor for the hedgehog signal
    Alcedo, J
    Ayzenzon, M
    VonOhlen, T
    Noll, M
    Hooper, JE
    [J]. CELL, 1996, 86 (02) : 221 - 232
  • [3] SOCS1 is a critical inhibitor of interferon γ signaling and prevents the potentially fatal neonatal actions of this cytokine
    Alexander, WS
    Starr, R
    Fenner, JE
    Scott, GL
    Handman, E
    Sprigg, NS
    Corbin, JE
    Cornish, AL
    Darwiche, R
    Owczarek, CM
    Kay, TWH
    Nicola, NA
    Hertzog, PJ
    Metcalf, D
    Hilton, DJ
    [J]. CELL, 1999, 98 (05) : 597 - 608
  • [4] Regulation of p53 stability
    Ashcroft, M
    Vousden, KH
    [J]. ONCOGENE, 1999, 18 (53) : 7637 - 7643
  • [5] COMPARTMENT BOUNDARIES AND THE CONTROL OF DROSOPHILA LIMB PATTERN BY HEDGEHOG PROTEIN
    BASLER, K
    STRUHL, G
    [J]. NATURE, 1994, 368 (6468) : 208 - 214
  • [6] Engineering stability in gene networks by autoregulation
    Becskei, A
    Serrano, L
    [J]. NATURE, 2000, 405 (6786) : 590 - 593
  • [7] Emergent properties of networks of biological signaling pathways
    Bhalla, US
    Iyengar, R
    [J]. SCIENCE, 1999, 283 (5400) : 381 - 387
  • [8] DOMAIN OF ULTRABITHORAX EXPRESSION IN DROSOPHILA VISCERAL MESODERM FROM AUTO-REGULATION AND EXCLUSION
    BIENZ, M
    TREMML, G
    [J]. NATURE, 1988, 333 (6173) : 576 - 578
  • [9] HOMEOTIC GENES AND POSITIONAL SIGNALING IN THE DROSOPHILA-VISCERA
    BIENZ, M
    [J]. TRENDS IN GENETICS, 1994, 10 (01) : 22 - 26
  • [10] Identification of SOCS-3 as a potential mediator of central leptin resistance
    Bjorbaek, C
    Elmquist, JK
    Frantz, JD
    Shoelson, SE
    Flier, JS
    [J]. MOLECULAR CELL, 1998, 1 (04) : 619 - 625
123456789