Extracellular ubiquitin regulates the growth of human hematopoietic cells

被引：21

作者：

Daino, H

Shibayama, H

Machii, T

Kitani, T

机构：

[1] Dept. of Hematology and Oncology, Osaka University Medical School, Suita

[2] Dept. of Hematology and Oncology, Osaka University Medical School, Suita, Osaka 565

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1996年 / 223卷 / 02期

关键词：

D O I：

10.1006/bbrc.1996.0875

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We investigated the effects of extracellular ubiquitin on the colony formation of human hematopoietic progenitor cells (CFU-GM, CFU-E and BFU-E) and a granulocyte-colony stimulating factor (G-CSF)-dependent human myeloblastic leukemic cell line, OCI/AML/1a. Ubiquitin exhibited inhibitory effects on CFU-GM, CFU-E, BFU-E and OCI/AML/1a colony formation. Extracellular ubiquitin also inhibited the growth of KT3 (T lymphoblast), K562 (erythroleukemia) and Daudi (Burkitt's lymphoma) cells, stimulated the growth of HL60 (promyelocytic leukemia) and Jurkat (T-ALL) cells and showed no effect on the growth of U937 cells (monocytic leukemia). These results indicate that another, previously unrecognized function of extracellular ubiquitin is to regulate hematopoiesis. (C) 1996 Academic Press, Inc.

引用

页码：226 / 228

页数：3

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