Gamma-delta T cells in midgestation human placental villi

被引：16

作者：

Bonney, EA ^{[1
]}

Pudney, J ^{[1
]}

Anderson, DJ ^{[1
]}

Hill, JA ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Obstet Gynecol & Reprod Biol, Boston, MA 02115 USA

来源：

GYNECOLOGIC AND OBSTETRIC INVESTIGATION | 2000年 / 50卷 / 03期

关键词：

human; immunohistochemistry; placenta; T cell receptor;

D O I：

10.1159/000010315

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

One question that remains is how the immune system at the maternal-fetal interface supports tolerance of the fetus while at the same time protecting it from infection. A potential answer is that local innate immunity is augmented while adaptive immunity is downregulated, In this study, we focus on T cells of the gamma-delta lineage, thought to be important in certain innate responses. Using tissue from normal pregnancies, we documented the presence of gamma-delta T cells and their counterpart, alpha-beta T cells, in midgestation human placental villi, The variable presence of these two T cell lineages in this anatomic site may suggest differential regulation, and herein we describe potential mechanisms for this phenomenon. Copyright (C) 2000 S. Karger AG, Basel.

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收藏

页码：153 / 157

页数：5

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