Aptamers in research and drug development

被引：32

作者：

Mayer, G

Jenne, A

机构：

[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

[2] NascaCell IP GmbH, Munich, Germany

来源：

BIODRUGS | 2004年 / 18卷 / 06期

关键词：

D O I：

10.2165/00063030-200418060-00002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aptamers are short single-stranded oligonucleotides that fold into well defined three-dimensional shapes allowing them to bind to and inhibit their targets with high affinity and specificity. Aptamers can be considered truly multifunctional tools, because they can be generated rapidly and applied for specific detection, inhibition, and characterization of proteins. Recent publications impressively confirm that aptamers can be used either as surrogate inhibitors for the identification of small molecule lead compounds or as biopharmaceuticals.

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收藏

页码：351 / 359

页数：9

相关论文

共 62 条

[1] In vitro display technologies:: novel developments and applications [J].

Amstutz, P ;

Forrer, P ;

Zahnd, C ;

Plückthun, A .

CURRENT OPINION IN BIOTECHNOLOGY, 2001, 12 (04) :400-405

[2] RNA molecules that bind to and inhibit the active site of a tyrosine phosphatase [J].

Bell, SD ;

Denu, JM ;

Dixon, JE ;

Ellington, AD .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (23) :14309-14314

[3] Systematic evolution of a DNA aptamer binding to rat brain tumor microvessels - Selective targeting of endothelial regulatory protein pigpen [J].

Blank, M ;

Weinschenk, T ;

Priemer, M ;

Schluesener, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (19) :16464-16468

[4] Cytoplasmic RNA modulators of an inside-out signal-transduction cascade [J].

Blind, M ;

Kolanus, W ;

Famulok, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (07) :3606-3610

[5]

BLIND M, 2002, SPEEDING FUNCTIONAL

[6] Photoaptamer arrays applied to multiplexed proteomic analysis [J].

Bock, C ;

Coleman, M ;

Collins, B ;

Davis, J ;

Foulds, G ;

Gold, L ;

Greef, C ;

Heil, J ;

Heilig, JS ;

Hicke, B ;

Hurst, MN ;

Husar, GM ;

Miller, D ;

Ostroff, R ;

Petach, H ;

Schneider, D ;

Vant-Hull, B ;

Waugh, S ;

Weiss, A ;

Wilcox, SK ;

Zichi, D .

PROTEOMICS, 2004, 4 (03) :609-618

[7] SELECTION OF SINGLE-STRANDED-DNA MOLECULES THAT BIND AND INHIBIT HUMAN THROMBIN [J].

BOCK, LC ;

GRIFFIN, LC ;

LATHAM, JA ;

VERMAAS, EH ;

TOOLE, JJ .

NATURE, 1992, 355 (6360) :564-566

[8]

Brody E N, 2000, J Biotechnol, V74, P5, DOI 10.1016/S1389-0352(99)00004-5

[9]

Burgstaller P, 2002, CURR OPIN DRUG DISC, V5, P690

[10] Aptamers as tools for target prioritization and lead identification [J].

Burgstaller, P ;

Girod, A ;

Blind, M .

DRUG DISCOVERY TODAY, 2002, 7 (24) :1221-1228

← 1 2 3 4 5 6 7 →