Aptamers in research and drug development

被引：32

作者：

Mayer, G

Jenne, A

机构：

[1] Univ Bonn, Kekule Inst Organ Chem & Biochem, D-53121 Bonn, Germany

[2] NascaCell IP GmbH, Munich, Germany

来源：

BIODRUGS | 2004年 / 18卷 / 06期

关键词：

D O I：

10.2165/00063030-200418060-00002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Aptamers are short single-stranded oligonucleotides that fold into well defined three-dimensional shapes allowing them to bind to and inhibit their targets with high affinity and specificity. Aptamers can be considered truly multifunctional tools, because they can be generated rapidly and applied for specific detection, inhibition, and characterization of proteins. Recent publications impressively confirm that aptamers can be used either as surrogate inhibitors for the identification of small molecule lead compounds or as biopharmaceuticals.

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收藏

页码：351 / 359

页数：9

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