The patched gene in development and cancer

被引：96

作者：

Ingham, PW ^{[1
]}

机构：

[1] Univ Sheffield, Krebs Inst, Dev Genet Programme, Sheffield S10 2TN, S Yorkshire, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 1998年 / 8卷 / 01期

关键词：

D O I：

10.1016/S0959-437X(98)80067-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The cloning of vertebrate homologues of the Drosophila segment polarity gene patched has led to confirmation of a role for the multipass transmembrane protein which it encodes as a receptor for secreted signalling proteins of the Hedgehog family. In addition, human patched has been identified as a tumour suppressor gene implicated in basal cell carcinomas and medullablastomas.

引用

页码：88 / 94

页数：7

共 49 条

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