Tacrine improves working memory deficit caused by permanent occlusion of bilateral common carotid arteries in rats

被引：20

作者：

Murakami, Y ^{[1
]}

Tanaka, E ^{[1
]}

Sakai, Y ^{[1
]}

Matsumoto, K ^{[1
]}

Li, HB ^{[1
]}

Watanabe, H ^{[1
]}

机构：

[1] Toyama Med & Pharmaceut Univ, Res Inst Wakan Yaku Oriental Med, Dept Pharmacol, Toyama 93001, Japan

来源：

JAPANESE JOURNAL OF PHARMACOLOGY | 1997年 / 75卷 / 04期

关键词：

permanent occlusion of bilateral common carotid arteries; spatial acquisition; tacrine;

D O I：

10.1254/jjp.75.443

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Effect of tacrine, a cholinesterase inhibitor, on spatial acquisition deficit caused by permanent occlusion of bilateral common carotid arteries (2VO) was examined by using the conventional 8-arm and the 4-arm baited radial maze tasks in rats. Daily administration of tacrine (0.1 and 0.3 mg/kg, i.p.) 1 month after 2VO operation significantly improved the impaired spatial acquisition in the conventional maze task. This treatment also ameliorated the 2VO-induced working but not reference memory deficit in the 4-arm baited radial maze task. These results suggest that tacrine improvement of working memory deficit in the 2VO rats is due to stimulation of central cholinergic systems.

引用

页码：443 / 446

页数：4

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