Cloning of a novel murine isoform of the glial cell line-derived neurotrophic factor receptor

被引：16

作者：

Dey, BK ^{[1
]}

Wong, YW ^{[1
]}

Too, HP ^{[1
]}

机构：

[1] Natl Univ Singapore, Fac Med, Dept Biochem, Singapore 119260, Singapore

来源：

NEUROREPORT | 1998年 / 9卷 / 01期

关键词：

brain; glial cell line-derived neurotrophic factor (GDNF) receptor; molecular cloning; Northern blot; reverse transcription PCR;

D O I：

10.1097/00001756-199801050-00008

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

WE report here the cloning of a novel form of the murine glial cell line-derived neurotrophic factor (GDNF) receptor. Northern blot analyses of various mouse tissues, including whole brain, demonstrated the existence of multiple transcripts of GDNF receptor. Screening of an adult mouse liver cDNA library yielded two isoforms of the receptor. One of the forms (alpha) shows a high degree of homology with other mammalian GDNFR-alpha and the other novel form (beta) is identical to the a form except for a deletion of five amino acids. These two forms do not share high sequence homologies with the recently isolated neurturin receptor. Both the alpha and beta forms are expressed in various murine tissues but not in muscle.

引用

页码：37 / 42

页数：6

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