Clinical research on antiangiogenic therapy

被引：38

作者：

Kuiper, RAJ ^{[1
]}

Schellens, JHM

Blijham, GH

Beijnen, JH

Voest, EE

机构：

[1] Slotervaart Hosp, Netherlands Canc Inst, Dept Pharm & Pharmacol, Amsterdam, Netherlands

[2] Netherlands Canc Inst, Dept Med Oncol, Amsterdam, Netherlands

[3] Univ Utrecht Hosp, Dept Internal Med & Med Oncol, Lab Angiogenesis Res, NL-3508 GA Utrecht, Netherlands

来源：

PHARMACOLOGICAL RESEARCH | 1998年 / 37卷 / 01期

关键词：

angiogenesis; cancer; pharmacology; clinical trials; design;

D O I：

10.1006/phrs.1997.0268

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A promising novel target for anti-cancer therapy is the tumour vasculature. Both primary tumour growth and the formation of metastasis depend on the establishment of new blood vessels from preexisting ones, a process called angiogenesis. Inhibition of angiogenesis and targeting of the tumour vasculature are highly effective in controlling tumour growth. Several natural and synthetic compounds have been developed and are currently tested in pre-clinical and clinical studies. This review intends to provide an overview of agents with antiangiogenic activity and the early clinical experience with these drugs. (C) 1998 The Italian Pharmacological Society.

引用

页码：1 / 16

页数：16

共 223 条

[31]

Collier M. A., 1997, Proceedings of the American Association for Cancer Research Annual Meeting, V38, P221

[32] INTERLEUKIN-1 IS AN AUTOCRINE REGULATOR OF HUMAN ENDOTHELIAL-CELL GROWTH [J].

COZZOLINO, F ;

TORCIA, M ;

ALDINUCCI, D ;

ZICHE, M ;

ALMERIGOGNA, F ;

BANI, D ;

STERN, DM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6487-6491

[33] A NEW CLASS OF STEROIDS INHIBITS ANGIOGENESIS IN THE PRESENCE OF HEPARIN OR A HEPARIN FRAGMENT [J].

CRUM, R ;

SZABO, S ;

FOLKMAN, J .

SCIENCE, 1985, 230 (4732) :1375-1378

[34] THALIDOMIDE IS AN INHIBITOR OF ANGIOGENESIS [J].

DAMATO, RJ ;

LOUGHNAN, MS ;

FLYNN, E ;

FOLKMAN, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :4082-4085

[35] CONTROL OF ANGIOGENESIS IN FIBROBLASTS BY P53 REGULATION OF THROMBOSPONDIN-1 [J].

DAMERON, KM ;

VOLPERT, OV ;

TAINSKY, MA ;

BOUCK, N .

SCIENCE, 1994, 265 (5178) :1582-1584

[36] THE P53 TUMOR-SUPPRESSOR GENE INHIBITS ANGIOGENESIS BY STIMULATING THE PRODUCTION OF THROMBOSPONDIN [J].

DAMERON, KM ;

VOLPERT, OV ;

TAINSKY, MA ;

BOUCK, N .

COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, 1994, 59 :483-489

[37] Cell-to-cell contact and extracellular matrix Editorial overview [J].

Damsky, Caroline H. ;

Bernfield, Merton .

CURRENT OPINION IN CELL BIOLOGY, 1991, 3 (05) :777-778

[38] Integrin beta 3 cDNA transfection into a highly metastatic alpha v beta 3-negative human melanoma cell line inhibits invasion and experimental metastasis [J].

Danen, EHJ ;

vanKraats, AA ;

Cornelissen, IMHA ;

Ruiter, DJ ;

vanMuijen, GNP .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 226 (01) :75-81

[39]

DAVIES B, 1993, CANCER RES, V53, P2087

[40] IN-VIVO CYTOKINE PRODUCTION AND RECOMBINANT INTERLEUKIN-2 IMMUNOTHERAPY - AN INSIGHT INTO THE POSSIBLE MECHANISMS UNDERLYING CLINICAL-RESPONSES [J].

DEEHAN, DJ ;

HEYS, SD ;

SIMPSON, WG ;

BROOM, J ;

FRANKS, C ;

EREMIN, O .

BRITISH JOURNAL OF CANCER, 1994, 69 (06) :1130-1135

← 1 2 3 4 5 6 7 8 9 10 →