Obesity: an epidemic in need of therapeutics

被引：20

作者：

Van der Ploeg, LHT ^{[1
]}

机构：

[1] Merck Res Labs, Dept Obes Res, Div Metab Disorders, Rahway, NJ 07065 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(00)00114-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent developments in the quest for control of human obesity include the discovery of hormones, neuropeptides, receptors and transcription factors involved in feeding behavior, metabolic rate and adipocyte development. As a result, obesity research is quickly developing a level of sophistication that is expected to yield new treatment approaches. Even though newly approved clinical interventions are being tested in the market place, the obesity epidemic continues to face numerous unmet clinical needs and awaits the development and implementation of safe and highly effective pharmacotherapy.

引用

页码：452 / 460

页数：9

共 120 条

[1] Narcolepsy and the hypocretin receptor 2 gene [J].

Aldrich, MS ;

Reynolds, PR .

NEURON, 1999, 23 (04) :625-626

[2] Weight loss increases and fat loss decreases all-cause mortality rate: results from two independent cohort studies [J].

Allison, DB ;

Zannolli, R ;

Faith, MS ;

Heo, M ;

Pietrobelli, A ;

VanItallie, TB ;

Pi-Sunyer, FX ;

Heymsfield, SB .

INTERNATIONAL JOURNAL OF OBESITY, 1999, 23 (06) :603-611

[3] In vivo modulation of Hmgic reduces obesity [J].

Anand, A ;

Chada, K .

NATURE GENETICS, 2000, 24 (04) :377-380

[4]

ARMSTRONG WF, 1999, CARDIOVASC REV REP, V20, P279

[5]

BICK JS, 1999, PRACT GASTROENTEROL, V23, P73

[6] Implication of tubby proteins as transcription factors by structure-based functional analysis [J].

Boggon, TJ ;

Shan, WS ;

Santagata, S ;

Myers, SC ;

Shapiro, L .

SCIENCE, 1999, 286 (5447) :2119-2125

[7]

BRAY GA, 1992, PROG BRAIN RES, V93, P333

[8] RECOMBINANT MOUSE OB PROTEIN - EVIDENCE FOR A PERIPHERAL SIGNAL LINKING ADIPOSITY AND CENTRAL NEURAL NETWORKS [J].

CAMPFIELD, LA ;

SMITH, FJ ;

GUISEZ, Y ;

DEVOS, R ;

BURN, P .

SCIENCE, 1995, 269 (5223) :546-549

[9] Pharmacogenetics introduction becomes pharmacogenomics: Wake up and get ready - Introduction [J].

Cantor, CR .

MOLECULAR DIAGNOSIS, 1999, 4 (04) :287-288

[10] The human obesity gene map:: The 1999 update [J].

Chagnon, YC ;

Pérusse, L ;

Weisnagel, SJ ;

Rankinen, T ;

Bouchard, C .

OBESITY RESEARCH, 2000, 8 (01) :89-117

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