Obesity: an epidemic in need of therapeutics

被引：20

作者：

Van der Ploeg, LHT ^{[1
]}

机构：

[1] Merck Res Labs, Dept Obes Res, Div Metab Disorders, Rahway, NJ 07065 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2000年 / 4卷 / 04期

关键词：

D O I：

10.1016/S1367-5931(00)00114-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent developments in the quest for control of human obesity include the discovery of hormones, neuropeptides, receptors and transcription factors involved in feeding behavior, metabolic rate and adipocyte development. As a result, obesity research is quickly developing a level of sophistication that is expected to yield new treatment approaches. Even though newly approved clinical interventions are being tested in the market place, the obesity epidemic continues to face numerous unmet clinical needs and awaits the development and implementation of safe and highly effective pharmacotherapy.

引用

页码：452 / 460

页数：9

共 120 条

[41] Recombinant leptin for weight loss in obese and lean adults - A randomized, controlled, dose-escalation trial [J].

Heymsfield, SB ;

Greenberg, AS ;

Fujioka, K ;

Dixon, RM ;

Kushner, R ;

Hunt, T ;

Lubina, JA ;

Patane, J ;

Self, B ;

Hunt, P ;

McCamish, M .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1999, 282 (16) :1568-1575

[42]

Hill JO, 1999, AM J CLIN NUTR, V69, P1108

[43] Environmental contributions to the obesity epidemic [J].

Hill, JO ;

Peters, JC .

SCIENCE, 1998, 280 (5368) :1371-1374

[44] Role of orlistat in the treatment of obese patients with type 2 diabetes - A 1-year randomized double-blind study [J].

Hollander, PA ;

Elbein, SC ;

Hirsch, IB ;

Kelley, D ;

McGill, J ;

Taylor, T ;

Weiss, SR ;

Crockett, SE ;

Kaplan, RA ;

Comstock, J ;

Lucas, CP ;

Lodewick, PA ;

Canovatchel, W ;

Chung, J ;

Hauptman, J .

DIABETES CARE, 1998, 21 (08) :1288-1294

[45] Targeted disruption of the melanocortin-4 receptor results in obesity in mice [J].

Huszar, D ;

Lynch, CA ;

FairchildHuntress, V ;

Dunmore, JH ;

Fang, Q ;

Berkemeier, LR ;

Gu, W ;

Kesterson, RA ;

Boston, BA ;

Cone, RD ;

Smith, FJ ;

Campfield, LA ;

Burn, P ;

Lee, F .

CELL, 1997, 88 (01) :131-141

[46] Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene [J].

Jackson, RS ;

Creemers, JWM ;

Ohagi, S ;

RaffinSanson, ML ;

Sanders, L ;

Montague, CT ;

Hutton, JC ;

ORahilly, S .

NATURE GENETICS, 1997, 16 (03) :303-306

[47] Novel polymorphisms in the neuropeptide-Y Y5 receptor associated with obesity in Pima Indians [J].

Jenkinson, CP ;

Cray, K ;

Walder, K ;

Herzog, H ;

Hanson, R ;

Ravussin, E .

INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (05) :580-584

[48] OPIOID INVOLVEMENT IN FEEDING-BEHAVIOR AND THE PATHOGENESIS OF CERTAIN EATING DISORDERS [J].

JOHNSON, RD .

MEDICAL HYPOTHESES, 1995, 45 (05) :491-497

[49] Role of the Y1 receptor in the regulation of neuropeptide Y-mediated feeding: Comparison of wild-type, Y1 receptor-deficient, and Y5 receptor-deficient mice [J].

Kanatani, A ;

Mashiko, S ;

Murai, N ;

Sugimoto, N ;

Ito, J ;

Fukuroda, T ;

Fukami, T ;

Morin, N ;

MacNeil, DJ ;

Van der Ploeg, LHT ;

Saga, Y ;

Nishimura, S ;

Ihara, M .

ENDOCRINOLOGY, 2000, 141 (03) :1011-1016

[50] Mechanism of insulin resistance in A-ZIP/F-1 fatless mice [J].

Kim, JK ;

Gavrilova, O ;

Chen, Y ;

Reitmann, ML ;

Shulman, GI .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (12) :8456-8460

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