Biochemical, cell biological and immunological issues surrounding the endoplasmic reticulum chaperone GRP94/gp96

被引：118

作者：

Nicchitta, CV ^{[1
]}

机构：

[1] Duke Univ, Med Ctr, Dept Cell Biol, Durham, NC 27710 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1998年 / 10卷 / 01期

关键词：

D O I：

10.1016/S0952-7915(98)80039-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The past year has born witness to compelling demonstrations of the utility of peptide complexes with glucose regulated protein 94 (GRP94, also known as gp96) in cancer immunotherapy. Insights into the structural basis of peptide binding to GRP94 have been obtained and the role of the transporter for antigen presentation in defining the GRP94-bound peptide composition has been determined.

引用

页码：103 / 109

页数：7

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